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HEMALIMIT products are an excellent oxidized cellulose based haemostatic agents. They are indicated as a haemostatic device used to arrest capillary and minor venous bleeding and parenchymateous or osseous bleeding from resected or injured organ surfaces during surgical interventions

Hemalimit Special Characteristics

The haemostatic effect is almost immediate
The haemostatic effect is almost immediate, the full haemostasis is achieved by 2 minutes after application
Is fully absorbed by 12 - 72 hours
Is fully absorbed by 12 – 72 hours, depending on the application form and wound extent
Is entirely eliminated from the body within 7 - 21 days
Is entirely eliminated from the body within 7 – 21 days, leaving no deposit behind in tissues and cells
Biocompatible, biodegradable
Is biocompatible, biodegradable, non-acidifying haemostatic preparation of natural origin
Is hypoallergenic – no sensitive features have been reported, no immune-reactions have been initiated, even after repeated application
Well tolerated by the organism
Is well tolerated by the organism and has a significant effect on healing process in wounds
Causes no irritating reactions
Causes no irritating reactions on the application area, no granulomas are formed
Bactericidal and bacteriostatic features
Has bactericidal and bacteriostatic features due to the presence of carboxyl groups
No adverse effects
No adverse effects as such have been reported
Alternative to bovine fibrins
Is an ideal alternative to bovine fibrins and collagens

How Does Hemalimit Work?

HEMALIMIT products’ effect consists in initiating and accelerating the haemocoagulation cascade.
HEMALIMIT has a significant role in starting haemocoagulation process. While applied, Factor VII is activated as well as the trombocyte activation is initiated by tissue factor. Due to anionactive characteristics of oxidized cellulose, HEMALIMIT is able to form complex polymers with compounds such as fibrinogen or haemoglobin, therefore fibrinogen polymerization is speeded up.

Higher Ca2+ ion concentration stabilizes activated Factor V and speeds up Factor XIII activity resulting in fibrinogen network stabilization which is therefore able to create sufficiently organized structure for fibroblast growth and cicatrix formation. During coagulation process Ca2+ ions partially participate in thrombocyte adhesion to collagens of exposed wound, and also show partial analgesic effect. That results from ion blockage effect on autonomous nerve-endings.

How Is Hemalimit Produced?

HEMALIMIT products are produced by selective oxidation of high-quality cotton material (99% of cellulose content at minimum). The principle of the process selectivity means that predominantly alcoholic group on 6th carbon of basic building unit is oxidized and carboxyl is formed (-COOH). The content of -COOH is maintained at 16 – 24 volume percentage according to USP

From the chemical point of view it is polyanhydroglucuronic acid (used for HEMALIMIT matrix), whose acidity is decreased by neutralization to calcium salt (used for HEMALIMIT powder). As free carboxyl group is a carrier of oxidized cellulose bactericidal effect, only a part of those groups is calcium bound, residual ones are free.

Areas of Application

Hemalimit is suitable for use in:

  • General surgery and digestive surgery
  • Plastic surgery
  • Orthopaedic surgery
  • Neurosurgery
  • Thoracic surgery
  • Vascular surgery
  • Gynaecology
  • Urology
  • All other branches of surgery
  • Traumatology and Stomatology

In dental praxis, the preparation shall be also used to arrest prolonged post-extraction capillary bleeding.


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