OXIDIZED CELLULOSE BASED HAEMOSTATS
HEMALIMIT products are an excellent oxidized cellulose based haemostatic agents. They are indicated as a haemostatic device used to arrest capillary and minor venous bleeding and parenchymateous or osseous bleeding from resected or injured organ surfaces during surgical interventions
Hemalimit Special Characteristics
The haemostatic effect is almost immediate
Is fully absorbed by 12 - 72 hours
Is entirely eliminated from the body within 7 - 21 days
Well tolerated by the organism
Causes no irritating reactions
Bactericidal and bacteriostatic features
No adverse effects
Alternative to bovine fibrins
How Does Hemalimit Work?
HEMALIMIT products’ effect consists in initiating and accelerating the haemocoagulation cascade.
HEMALIMIT has a significant role in starting haemocoagulation process. While applied, Factor VII is activated as well as the trombocyte activation is initiated by tissue factor. Due to anionactive characteristics of oxidized cellulose, HEMALIMIT is able to form complex polymers with compounds such as fibrinogen or haemoglobin, therefore fibrinogen polymerization is speeded up.
Higher Ca2+ ion concentration stabilizes activated Factor V and speeds up Factor XIII activity resulting in fibrinogen network stabilization which is therefore able to create sufficiently organized structure for fibroblast growth and cicatrix formation. During coagulation process Ca2+ ions partially participate in thrombocyte adhesion to collagens of exposed wound, and also show partial analgesic effect. That results from ion blockage effect on autonomous nerve-endings.
How Is Hemalimit Produced?
HEMALIMIT products are produced by selective oxidation of high-quality cotton material (99% of cellulose content at minimum). The principle of the process selectivity means that predominantly alcoholic group on 6th carbon of basic building unit is oxidized and carboxyl is formed (-COOH). The content of -COOH is maintained at 16 – 24 volume percentage according to USP
From the chemical point of view it is polyanhydroglucuronic acid (used for HEMALIMIT matrix), whose acidity is decreased by neutralization to calcium salt (used for HEMALIMIT powder). As free carboxyl group is a carrier of oxidized cellulose bactericidal effect, only a part of those groups is calcium bound, residual ones are free.